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Institut Charles Sadron

Institut Charles Sadron Membre

Delphine Chan-Seng

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Equipe : IRIS

Delphine Chan-Seng received a B.Sc. degree in chemistry (2000) and a M.Sc. degree in Polymer Sciences (2002) from the University of Bordeaux (France). During her MSc, she spent 5 months working in the Macromolecular Chemistry II laboratory (University of Bayreuth, Germany) on the synthesis of hyperbranched polymers grafted on silica nanoparticles under the supervision of Axel H. E. Müller and Hideharu Mori, and 7 months at the Laboratoire de Chimie des Polymères Organiques (University of Bordeaux, France) under the supervision of Henri Cramail and Eric Cloutet on the synthesis of polyurethane particles in dispersed medium. She earned her Ph.D. degree in Polymer Chemistry (2007) from the University of Toronto (Canada) working under the direction of Michael K. Georges, where her thesis work dealt with controlled radical polymerization focusing on atom transfer radical polymerization under seeded emulsion conditions and the investigation of acrylates polymerization under nitroxide-mediated polymerization conditions. She then conducted postdoctoral research in the group of Todd Emrick at the University of Massachusetts at Amherst, where she focused on the synthesis of polymers for targeted applications, such as the synthesis of aliphatic polyesters and their post-polymerization functionalization used as coatings for drug-elution cardiovascular stents, and the synthesis of peptide-based comb polymers used as non-viral vectors for gene therapy. In 2011, she joined the Institut Charles Sadron as a CNRS researcher.

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CURRENT RESEARCH

We are interested in developing polymers based on synthetic and natural building blocks combining organic chemistry, solid-phase peptide synthesis and polymer chemistry to further modulate the composition, topology and functionality of polymers and thus promote specific intrinsic properties to these polymers. Amino acid- and peptide-based polymers are aimed to find applications in biomedicine (e.g. delivery of small drugs, theranostics, gene therapy, cell adhesion, materials with antimicrobial activities), while the development of novel compatibilizers is targeted for composite materials and polymer blends.

Research interest keywords: polymer synthesis, macromolecular engineering, post-polymerization modification, solid-phase synthesis, polymers for targeted applications

Publications

2025

Journal articles

titre: Experimental and Computational Study of Injectable Iron(III)/Ultrashort Peptide Hydrogels: A Candidate for Ferroptosis‐Induced Treatment of Bacterial Infections
auteur: Capucine Loth, Florent Barbault, Cécile Guégan, Flora Lemaire, Christophe Contal, Alain Carvalho, Sophie Hellé, Marie Champion, Halima Kerdjoudj, Delphine Chan-Seng, Lydie Ploux, Fouzia Boulmedais
article: Small Science, In press, ⟨10.1002/smsc.202400618⟩
Resume_court: Injectable hydrogels are promising candidates as local drug delivery platforms for the treatment of .....
typdoc: Journal articles
DOI: DOI : 10.1002/smsc.202400618
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titre: Counteranion effect on the RAFT polymerization of methacrylate-g-pentaarginine and its UCST-type thermoresponsive behavior
auteur: Amélie Augé, Tetiana Dorosh, Ayoub Rachdi, Quentin Bievelot, Alain Chaumont, Fouzia Boulmedais, Delphine Chan-Seng
article: European Polymer Journal, 2025, 238, pp.114202. ⟨10.1016/j.eurpolymj.2025.114202⟩
Resume_court: Poly(methacrylate-g-pentaarginine) prepared by reversible addition-fragmentation chain transfer (RAF .....
typdoc: Journal articles
DOI: DOI : 10.1016/j.eurpolymj.2025.114202
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2024

Journal articles

titre: Simultaneous photo-induced polymerization and surface modification by microfluidic spinning to produce functionalized polymer microfibers: the effect of their surface modification on cell adhesion
auteur: Wasif Razzaq, Christophe A Serra, Candice Dussouillez, Naji Kharouf, Irene Andrea Acuña Mejía, Antoine Kichler, Delphine Chan-Seng
article: RSC Applied Polymers, 2024, 2 (1), pp.62-70. ⟨10.1039/d3lp00032j⟩
Resume_court: A capillary-based microfluidic device is used to prepare functionalized polymer microfibers in one-s .....
typdoc: Journal articles
DOI: DOI : 10.1039/d3lp00032j
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2023

Journal articles

titre: Model reactions for the evaluation of poly- and multifunctional molecules as potential interfacial agents for the compatibilization of polyethylene/poly(ethylene-co-vinyl alcohol) blends†
auteur: Elisa Gitzhofer, Bertrand Vileno, Michel Bouquey, Delphine Chan-Seng
article: Polymer Chemistry, 2023, 14, pp.934-942. ⟨10.1039/d2py01495e⟩
Resume_court: In aiming to identify an interfacial agent for polyethylene (PE)/poly(ethylene-co-vinyl alcohol) (EV .....
typdoc: Journal articles
DOI: DOI : 10.1039/d2py01495e
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2022

Journal articles

titre: Microfluidic Janus fibers with dual thermoresponsive behavior for thermoactuation
auteur: Wasif Razzaq, Christophe A Serra, Delphine Chan-Seng
article: European Polymer Journal, 2022, 174, pp.111321. ⟨10.1016/j.eurpolymj.2022.111321⟩
Resume_court: Thermoresponsive bilayer hydrogels have gained attention due to their fast response time and excelle .....
typdoc: Journal articles
DOI: DOI : 10.1016/j.eurpolymj.2022.111321
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titre: Production of Janus/Hecate microfibers by microfluidic photopolymerization and evaluation of their potential in dyes removal
auteur: Wasif Razzaq, Christophe Serra, Delphine Chan-Seng
article: Chemical Communications, 2022, 58 (29), pp.4619-4622. ⟨10.1039/D2CC00214K⟩
Resume_court: The production of Janus/Hecate polymer microfibers with well-defined interfaces by microfluidic phot .....
typdoc: Journal articles
DOI: DOI : 10.1039/D2CC00214K
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2021

Journal articles

titre: Controlled synthesis of NaYF 4 :Yb,Er upconversion nanocrystals as potential probe for bioimaging: A focus on heat treatment
auteur: Alireza Kavand, Christophe A Serra, Christian Blanck, Marc Lenertz, Nicolas Anton, Thierry F Vandamme, Yves Mély, Frédéric Przybilla, Delphine Chan-Seng
article: ACS Applied Nano Materials, 2021, 4 (5), pp.5319-5329. ⟨10.1021/acsanm.1c00664⟩
Resume_court: Upconversion nanoparticles are a promising class of materials for bioimaging. Their attractive optic .....
typdoc: Journal articles
DOI: DOI : 10.1021/acsanm.1c00664
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titre: Insertion of hydrophobic spacers on dodecalysines as potential transfection enhancers
auteur: Clothilde Le Guen, Candice Dussouillez, Antoine Kichler, Delphine Chan-Seng
article: European Polymer Journal, 2021, 157, pp.110654. ⟨10.1016/j.eurpolymj.2021.110654⟩
Resume_court: The use of cationic polymers in gene therapy aims at improving the circulation, protection and deliv .....
typdoc: Journal articles
DOI: DOI : 10.1016/j.eurpolymj.2021.110654
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titre: Adsorption of phenylalanine-rich sequence-defined oligomers onto Kevlar fibers for fiber-reinforced polyolefin composite materials
auteur: Jeroen Louwsma, Alain Carvalho, Jean-François Lutz, Stéphane Joly, Delphine Chan-Seng
article: Polymer, 2021, 217, pp.123465. ⟨10.1016/j.polymer.2021.123465⟩
Resume_court: Oligomers comprising four or sixteen phenylalanine residues with regularly intercalated aliphatic ch .....
typdoc: Journal articles
DOI: DOI : 10.1016/j.polymer.2021.123465
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2020

Journal articles

titre: Tuning polymers grafted on upconversion nanoparticles for the delivery of 5-fluorouracil
auteur: Alireza Kavand, Nicolas Anton, Thierry Vandamme, Christophe Serra, Delphine Chan-Seng
article: European Polymer Journal, 2020, 137, pp.109935. ⟨10.1016/j.eurpolymj.2020.109935⟩
Resume_court: Efficient and safe delivery of anticancer drugs such as 5-fluorouracil (5-FU) is still a challenge i .....
typdoc: Journal articles
DOI: DOI : 10.1016/j.eurpolymj.2020.109935
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titre: Investigating the growth of hyperbranched polymers by self-condensing vinyl RAFT copolymerization from the surface of upconversion nanoparticles
auteur: Alireza Kavand, Christian Blanck, Frédéric Przybilla, Yves Mély, Nicolas Anton, Thierry Vandamme, Christophe Serra, Delphine Chan-Seng
article: Polymer Chemistry, 2020, 11 (26), pp.4313-4325. ⟨10.1039/d0py00452a⟩
Resume_court: Hyperbranched poly(N-(2-hydroxypropyl) methacrylamide)s grafted on upconversion nanoparticles (UCNPs .....
typdoc: Journal articles
DOI: DOI : 10.1039/d0py00452a
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titre: Production of lipophilic nanogels by spontaneous emulsification
auteur: Shukai Ding, Bilal Mustafa, Nicolas Anton, Christophe Serra, Delphine Chan-Seng, Thierry Vandamme
article: International Journal of Pharmaceutics, 2020, 585, pp.119481. ⟨10.1016/j.ijpharm.2020.119481⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.ijpharm.2020.119481
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titre: Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo
auteur: Marxa L Figueiredo, Manoel Eulálio Neto, Janelle Wes Salameh, Richard E Decker, Rachel Letteri, Delphine Chan-Seng, Todd Emrick
article: Molecular Therapy - Methods and Clinical Development, 2020, 17, pp.739-751. ⟨10.1016/j.omtm.2020.03.022⟩
Resume_court: We have examined the role of a novel targeted cytokine, inter-leukin-27 (IL-27), modified at the C t .....
typdoc: Journal articles
DOI: DOI : 10.1016/j.omtm.2020.03.022
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titre: SYNTHESIS AND FUNCTIONALIZATION OF HYPERBRANCHED POLYMERS FOR TARGETED DRUG DELIVERY
auteur: Alireza Kavand, Nicolas Anton, Thierry Vandamme, Christophe Serra, Delphine Chan-Seng
article: Journal of Controlled Release, 2020, 321, pp.285-311. ⟨10.1016/j.jconrel.2020.02.019⟩
Resume_court: Hyperbranched polymers (HBPs) have found use in a wide range of applications, such as optical, elect .....
typdoc: Journal articles
DOI: DOI : 10.1016/j.jconrel.2020.02.019
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titre: Unexpected aqueous UCST behavior of a cationic comb polymer with pentaarginine side chains
auteur: Nicolas Zydziak, Muhammad Haseeb Iqbal, Alain Chaumont, Antoine Combes, Emeric Wasielewski, Mélanie Legros, Loïc Jierry, Philippe Lavalle, Fouzia Boulmedais, Delphine Chan-Seng
article: European Polymer Journal, 2020, 125, pp.109528. ⟨10.1016/j.eurpolymj.2020.109528⟩
Resume_court: Thermoresponsive polymers, undergoing a reversible chemical or physical change using temperature as .....
typdoc: Journal articles
DOI: DOI : 10.1016/j.eurpolymj.2020.109528
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2018

Journal articles

titre: Synthesis of Macromolecules Containing Phenylalanine and Aliphatic Building Blocks
auteur: Delphine Chan-Seng, Jeroen Louwsma, Jean-François Lutz, Stéphane Joly
article: Macromolecular Rapid Communications, 2018, 39 (8), pp.1700764. ⟨10.1002/marc.201700764⟩
Resume_court: Aiming at developing efficient interfacial agents for fiber‐reinforced composite materials, macrom .....
typdoc: Journal articles
DOI: DOI : 10.1002/marc.201700764
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2016

Journal articles

titre: Orthogonal Synthesis of Xeno Nucleic Acids
auteur: Guillaume Fiers, Dalila Chouikhi, Laurence Oswald, Abdelaziz Al Ouahabi, Delphine Chan-Seng, Laurence Charles, Jean-Francois Lutz
article: Chemistry - A European Journal, 2016, 22 (50), pp.17945-17948. ⟨10.1002/chem.201604386⟩
Resume_court: Sequence-defined peptide triazole nucleic acids (PTzNA) were synthesized by means of a solid-phase o .....
typdoc: Journal articles
DOI: DOI : 10.1002/chem.201604386
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titre: Dispersing Zwitterions into Comb Polymers for Nonviral Transfection: Experiments and Molecular Simulation
auteur: Ahmadreza F. Ghobadi, Rachel Letteri, Sangram S. Parelkar, Yue Zhao, Delphine Chan-Seng, Todd Emrick, Arthi Jayaraman
article: Biomacromolecules, 2016, 17 (2), pp.546-557. ⟨10.1021/acs.biomac.5b01462⟩
typdoc: Journal articles
DOI: DOI : 10.1021/acs.biomac.5b01462
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2015

Journal articles

titre: Debromination of ATRP-made Wang soluble polymer supports
auteur: Laurence Oswald, Thanh Tam Trinh, Delphine Chan-Seng, Jean-François Lutz
article: Polymer, 2015, 72, pp.341-347. ⟨10.1016/j.polymer.2015.02.057⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.polymer.2015.02.057
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titre: Preparation of Information-Containing Macromolecules by Ligation of Dyad-Encoded Oligomers
auteur: Thanh Tam Trinh, Laurence Oswald, Delphine Chan-Seng, Laurence Charles, Jean-François Lutz
article: Chemistry - A European Journal, 2015, 21 (34), pp.11961--11965. ⟨10.1002/chem.201502414⟩
Resume_court: A simplified strategy for preparing non-natural information-containing polymers is reported. The con .....
typdoc: Journal articles
DOI: DOI : 10.1002/chem.201502414
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titre: Sonodelivery Facilitates Sustained Luciferase Expression from an Episomal Vector in Skeletal Muscle
auteur: Manoel Neto, Rachel Letteri, Delphine Chan-Seng, Todd Emrick, Marxa Figueiredo
article: Materials, 2015, 8 (7), pp.4608-4617. ⟨10.3390/ma8074608⟩
typdoc: Journal articles
DOI: DOI : 10.3390/ma8074608
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2014

Journal articles

titre: Polymer–Peptide Delivery Platforms: Effect of Oligopeptide Orientation on Polymer-Based DNA Delivery
auteur: Sangram S. Parelkar, Rachel Letteri, Delphine Chan-Seng, Olga Zolochevska, Jayne Ellis, Marxa Figueiredo, Todd Emrick
article: Biomacromolecules, 2014, 15 (4), pp.1328-1336. ⟨10.1021/bm401878p⟩
typdoc: Journal articles
DOI: DOI : 10.1021/bm401878p
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titre: Primary Structure Control of Oligomers Based on Natural and Synthetic Building Blocks
auteur: Delphine Chan-Seng, Jean-François Lutz
article: ACS Macro Letters, 2014, 3 (3), pp.291-294. ⟨10.1021/mz5000575⟩
typdoc: Journal articles
DOI: DOI : 10.1021/mz5000575
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titre: Synthesis of Molecularly Encoded Oligomers Using a Chemoselective “AB + CD” Iterative Approach
auteur: Thanh Tam Trinh, Laurence Oswald, Delphine Chan-Seng, Jean-François Lutz
article: Macromolecular Rapid Communications, 2014, 35 (2), pp.141-145. ⟨10.1002/marc.201300774⟩
typdoc: Journal articles
DOI: DOI : 10.1002/marc.201300774
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Book sections

titre: Solid-Phase Synthesis as a Tool for the Preparation of Sequence-Defined Oligomers Based on Natural Amino Acids and Synthetic Building Blocks
auteur: Delphine Chan-Seng, Jean-François Lutz
article: Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties, ACS Symposium SeriesVol. 1170, pp.103-116, 2014, ⟨10.1021/bk-2014-1170.ch007⟩
typdoc: Book sections
DOI: DOI : 10.1021/bk-2014-1170.ch007
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2013

Journal articles

titre: Interleukin-27 Gene Delivery for Modifying Malignant Interactions Between Prostate Tumor and Bone
auteur: Olga Zolochevska, Jayne Ellis, Sangram Parelkar, Delphine Chan-Seng, Todd Emrick, Jingna Wei, Igor Patrikeev, Massoud Motamedi, Marxa L. Figueiredo
article: Human Gene Therapy, 2013, 24 (12), pp.970-981. ⟨10.1089/hum.2013.091⟩
typdoc: Journal articles
DOI: DOI : 10.1089/hum.2013.091
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titre: Examination of zwitterionic polymers and gels subjected to mechanical constraints
auteur: Dingzhi Han, Rachel Letteri, Delphine Chan-Seng, Todd Emrick, Huilin Tu
article: Polymer, 2013, 54 (12), pp.2887-2894. ⟨10.1016/j.polymer.2013.04.003⟩
typdoc: Journal articles
DOI: DOI : 10.1016/j.polymer.2013.04.003
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titre: Microstructure Control: An Underestimated Parameter in Recent Polymer Design
auteur: Nezha Badi, Delphine Chan-Seng, Jean-François Lutz
article: Macromolecular Chemistry and Physics, 2013, 214 (2), pp.135-142. ⟨10.1002/macp.201200475⟩
typdoc: Journal articles
DOI: DOI : 10.1002/macp.201200475
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Book sections

titre: Functional Polymers with Controlled Microstructure Based on Styrene and N -Substituted Maleimides
auteur: Delphine Chan-Seng, Mirela Zamfir, Jean-François Lutz
article: Functional Polymers by Post-Polymerization Modification, Wiley-VCH Verlag GmbH & Co. KGaA, pp.173-192, 2013, ⟨10.1002/9783527655427.ch7⟩
typdoc: Book sections
DOI: DOI : 10.1002/9783527655427.ch7
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2012

Journal articles

titre: Polymer-Chain Encoding: Synthesis of Highly Complex Monomer Sequence Patterns by Using Automated Protocols
auteur: Delphine Chan-Seng, Mirela Zamfir, Jean-François Lutz
article: Angewandte Chemie International Edition, 2012, 51 (49), pp.12254-12257. ⟨10.1002/anie.201206371⟩
typdoc: Journal articles
DOI: DOI : 10.1002/anie.201206371
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titre: Influence of Strong Electron-Donor Monomers in Sequence-Controlled Polymerizations
auteur: Sansanee Srichan, Delphine Chan-Seng, Jean-François Lutz
article: ACS Macro Letters, 2012, 1 (5), pp.589-592. ⟨10.1021/mz3001513⟩
typdoc: Journal articles
DOI: DOI : 10.1021/mz3001513
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